A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains
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چکیده
منابع مشابه
Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.
Eliciting a broadly neutralizing polyclonal antibody response against HIV-1 remains a major challenge. One approach to vaccine development is prevention of HIV-1 entry into cells by blocking the fusion of viral and cell membranes. More specifically, our goal is to elicit neutralizing antibodies that target a transient viral entry intermediate (the prehairpin intermediate) formed by the HIV-1 gp...
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The HIV-1 envelope glycoprotein (Env) gp41 plays a crucial role in the viral fusion process. The peptides derived from the C-terminal heptad repeat (CHR) of gp41 are potent HIV fusion inhibitors. However, the activity of these anti-HIV-1 peptides in vivo may be attenuated by their induction of anti-gp41 antibodies. Thus, it is essential to identify antiviral peptides or proteins with low, or no...
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Most antibodies induced by HIV-1 are ineffective at preventing initiation or spread of infection because they are either nonneutralizing or narrowly isolate-specific. Rare, "broadly neutralizing" antibodies have been detected that recognize relatively conserved regions on the envelope glycoprotein. Using stringently characterized, homogeneous preparations of trimeric HIV-1 envelope protein in r...
متن کاملCharacterization of Immune Responses Induced by Combined Clade-A HIV-1 Recombinant Adenovectors in Mice
Background: Numerous evidences indicate that in some HIV-1 positive patients, the humoral and cellular immune responses are induced against HIV-1 proteins and this is inversely related to the progress of infection. Objective: The aim of this study was the evaluation of the Adenovectors containing HIV genes in induction of immune responses in mice. Methods: The HIV-1 genes including gag p24, rev...
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A novel chimeric protein-based HIV-1 fusion inhibitor targeting gp41 with high potency and stability Chungen Pan, Lifeng Cai, Hong Lu, Lu Lu, and Shibo Jiang* From Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065 MOE/MOH Key Laboratory of Medical Molecular Virology and Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032,...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2012
ISSN: 1742-4690
DOI: 10.1186/1742-4690-9-104